Effect of bradykinin on the sodium channel current in dorsal root ganglion neuron / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 337-340, 2003.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-333758
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the effects of bradykinin on voltage-dependent sodium channel currents in rat dorsal root ganglion neurons (DRG).</p><p><b>METHODS</b>Whole-cell patch clamp technique was used to determine sodium channel current.</p><p><b>RESULTS</b>Bradykinin at 0.01 - 10.0 micromol/L dose dependently increased the frequency of repetitive firing of DRG. Bradykinin at 0.01 - 10.0 micromol/L dose dependently enhanced the TTX-R sodium current, and had no effect on TTX-S sodium current.</p><p><b>CONCLUSION</b>Mechanism underlying the inflammation induced by bradykinin is related to the TTX-R sodium channel.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Action Potentials
/
Bradykinin
/
Sodium Channels
/
Rats, Sprague-Dawley
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Patch-Clamp Techniques
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Ganglia, Spinal
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Membrane Potentials
/
Neurons
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2003
Document type:
Article