An investigation on the division of neuronal PC12 cells induced by nerve growth factor / 生理学报
Acta Physiologica Sinica
; (6): 552-556, 2005.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-334134
Responsible library:
WPRO
ABSTRACT
Neuronal PC12 cells induced by nerve growth factor (NGF) have been considered to be postmitotic and lack the ability to divide. However, in this study, we not only detected DNA synthesis but also observed cell division in some morphologically differentiated neuronal PC12 cells bearing long neurites. More interestingly, in addition to the division of perikaryon, the neurites located on the division site of the cell membrane also divided into two parts and were allocated to the two daughter cells. These results demonstrate that the morphologically differentiated neuronal PC12 cells still retain the ability to divide. This is the first report that neuronal PC12 cells as well as their neurites can divide.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Cell Differentiation
/
Cell Division
/
PC12 Cells
/
Neurites
/
Nerve Growth Factor
/
Cell Biology
/
DNA Replication
/
Neurons
Limits:
Animals
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2005
Document type:
Article