Relationship between the quantities of virus and the models of serologic markers in patients infected with HBV / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 269-271, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-334231
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between the quantities of HBV and the models of serologic markers.</p><p><b>METHODS</b>Real-time fluorescent quantitative PCR was used to measure the HBV DNA and ELISA was used to detect the antigen/antibody of HBV.</p><p><b>RESULTS</b>The patients whose HBV copies were more than 10(3)/ml accounted for 87.3%, whose copies were more than 10(7)/ml accounted for 66.7% among the HBsAg and HBeAg -positive patients. The patients whose HBV copies were less than 10(3)/ml accounted for 74.5%, whose HBV copies were more than 10(7)/ml accounted for 8.3% among the HBeAg-negative patients. The HBV copies of HBeAg-positive patients were significantly more than HBeAg-negative patients (P<0.01). The HBV copies of anti-HBe-negative patients were significantly more than anti-HBe-positive patients (P<0.01). The HBV DNA was detected in some HBsAg-negative patients. One patient's HBV copies were as high as 1.59 10(9)/ml.</p><p><b>CONCLUSIONS</b>The HBV copies of HBeAg-positive patients are significantly more than HBeAg-negative patients, The HBV copies of anti-HBe-negative patients are significantly more than the anti-HBe-positive patients. However, some HBeAg-positive patient's HBV copies are very low, and some HBeAg-negative patient's HBV copies are very high. HBV DNA even could be detected in some HBsAg-negative patients. It is difficult to judge accurately the quantities of HBV and infectivity according to the serologic markers for a specific patient.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Virology
/
DNA, Viral
/
Enzyme-Linked Immunosorbent Assay
/
Allergy and Immunology
/
Hepatitis B
/
Hepatitis B e Antigens
/
Hepatitis B Surface Antigens
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Hepatology
Year:
2002
Document type:
Article