Study on the relationship between aspirin resistance and incidence of myonecrosis after non-emergent percutaneous coronary intervention / 中华心血管病杂志
Chinese Journal of Cardiology
; (12): 695-699, 2005.
Article
in Zh
| WPRIM
| ID: wpr-334629
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the occurrence of aspirin resistance in coronary heart disease (CHD) patients and its influence on myonecrosis among patients undergoing non-emergent percutaneous coronary intervention (PCI).</p><p><b>METHODS</b>256 CHD patients who have been on aspirin (100 mg/d) for at least 7 days were recruited based on aspirin responsiveness determination. All the patients were divided into two groups: aspirin-resistant group and aspirin-sensitive group. For all patients scheduled for non-emergent PCI, a loading dose of 300 mg of clopidogrel was given at least 12 h before PCI and a 75 mg maintenance dose was given every morning before and after PCI. The incidence of myonecrosis was evaluated by the levels of creatine kinase-myocardial band (CK-MB) and troponin I (TnI) before and after PCI.</p><p><b>RESULTS</b>Aspirin resistance was found in 67 (26.2%) patients and 189 (73.8%) patients were aspirin-sensitive. There was a significantly higher proportion of female subjects in the aspirin-resistant group. The incidence of any CK-MB elevation was 38 (56.7%) in aspirin-resistant group and 42 (22.2%) in aspirin-sensitive group (P < 0.01). The elevation of TnI was observed in 41 (61.2%) of the aspirin-resistant group and in 67 (35.4%) of the aspirin-sensitive group (P < 0.05). Multivariate analysis revealed that aspirin resistance was an independent predictor for CK-MB elevation after PCI (OR = 2.5; 95% CI 1.5 to 6.5; P < 0.05).</p><p><b>CONCLUSION</b>Aspirin resistance exists in some CHD patients, which increases the risk of myonecrosis following non-emergent PCI.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
/
Pharmacology
/
Therapeutics
/
Drug Resistance
/
Angioplasty, Balloon, Coronary
/
Platelet Activation
/
Stents
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Platelet Aggregation
/
Aspirin
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Multivariate Analysis
Type of study:
Incidence_studies
/
Prognostic_studies
Limits:
Aged
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Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Cardiology
Year:
2005
Document type:
Article