Expression of hypoxia inducible factor-1α and insulin in pancreatic cancer and their correlation / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 348-351, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-335282
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the correlation between the expressions of hypoxia inducible factor-1α (HIF-1α) and insulin in pancreatic cancer.</p><p><b>METHODS</b>HIF-1α and insulin expression was detected by immunohistochemistry in the center and the edge of pancreatic adenocarcinoma specimens of 65 cases. Western blot was used to detect HIF-1α expression and insulin level in the center and the edge of pancreatic adenocarcinoma specimens of 28 cases. The relationship between HIF-1α expression and insulin level in the pancreatic cancer was analyzed.</p><p><b>RESULTS</b>The results of immunohistochemistry and Western blot showed that HIF-1α protein expression was high in both the center and the edge of pancreatic cancers (P > 0.05), and insulin level was significantly higher at the edge of specimen than that in the center (P < 0.05). HIF-1α protein and insulin levels were positively correlated at the edge of cancer tissue (r = 0.374, P < 0.05), but no significant correlation between them in the center of cancerous tissue (r = -0.145, P > 0.05).</p><p><b>CONCLUSION</b>Insulin may promote the local invasion and metastasis of pancreatic cancer by up-regulating HIF-1α.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pancreatic Neoplasms
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Pathology
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Immunohistochemistry
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Adenocarcinoma
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Blotting, Western
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Hypoxia-Inducible Factor 1, alpha Subunit
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Insulin
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Metabolism
Limits:
Adult
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Aged
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2012
Document type:
Article