Comparison of the effect of palonosetron versus tropisetron in prevention of vomiting in patients receiving high dose cisplatin-based chemotherapy / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 228-231, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-335307
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of palonosetron for prevention of vomiting induced by high dose cisplatin-based chemotherapy.</p><p><b>METHODS</b>One-hundred and twenty-eight patients received tropisetron 5 mg plus dexamethasone 10 mg at the first cycle or palonosetron 0.25 mg plus dexamethasone 10 mg, respectively, each administered 30 min before the initiation of high dose cisplatin-based chemotherapy. To observe the remission rate of acute emetic episodes and delayed emetic episodes, adverse effects and daily food-intake in the patients after the chemotherapy.</p><p><b>RESULTS</b>The complete response (CR) rates for acute vomiting were not significantly different between the tropisetron and palonosetron cycles (75.8% vs. 79.7%, P>0.05). The complete control rate of delayed vomiting in the palonosetron cycle was significantly higher than that in the tropisetron cycle (70.3% vs. 50.8%, P<0.01). The food-intake decrease rate of palonosetron cycle was 18.8%, significantly lower than the 53.1% of the tropisetron cycle (P<0.05). The toxicity in the two cycles was similar and no grade 3-4 toxicity was observed.</p><p><b>CONCLUSIONS</b>Palonosetron is superior to tropisetron with a lower remission rate of delayed emesis induced by high dose cisplatin-based chemotherapy and with tolerable toxicity. Moreover, the apparent emesis control of palonosetron treatment seems to provide an adequate food-intake in these patients.</p>
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
/
SDG3 - Health and Well-Being
Health problem:
Goal 9: Noncommunicable diseases and mental health
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Target 3.4: Reduce premature mortality due to noncommunicable diseases
Database:
WPRIM (Western Pacific)
Main subject:
Quinuclidines
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Vomiting
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Cisplatin
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Therapeutic Uses
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Drug Therapy
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Eating
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Indoles
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Isoquinolines
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Antiemetics
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Neoplasms
Limits:
Aged
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2012
Document type:
Article