Neuroprotective role of silent information regulator 1 in Alzheimer's disease / 生理学报
Acta Physiologica Sinica
; (6): 396-400, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-335974
Responsible library:
WPRO
ABSTRACT
Silent information regulator 1 (SIRT1), an NAD(+)-dependent deacetylase, is involved in the regulation of gene transcription, energy metabolism and cell aging. Recent studies have showed that SIRT1 possesses neuroprotective effects, however, it is not very clear how SIRT1 exerts the neuroprotection in Alzheimer's disease (AD). In this review, we summarized the neuroprotective role of SIRT1 in AD and its possible molecular mechanisms, proposing a novel strategy for preventing and treating neurodegeneration.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Transcription, Genetic
/
Neuroprotective Agents
/
Energy Metabolism
/
Sirtuin 1
/
Alzheimer Disease
/
Genetics
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2011
Document type:
Article