Comparison of concurrent chemoradiotherapy versus sequential radiochemotherapy in patients with completely resected non-small cell lung cancer
Radiation Oncology Journal
; : 202-208, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-33614
Responsible library:
WPRO
ABSTRACT
PURPOSE:
Our institution has implemented two different adjuvant protocols in treating patients with non-small cell lung cancer (NSCLC) chemotherapy followed by concurrent chemoradiotherapy (CT-CCRT) and sequential postoperative radiotherapy (PORT) followed by postoperative chemotherapy (POCT). We aimed to compare the clinical outcomes between the two adjuvant protocols. MATERIALS ANDMETHODS:
From March 1997 to October 2012, 68 patients were treated with CT-CCRT (n = 25) and sequential PORT followed by POCT (RT-CT; n = 43). The CT-CCRT protocol consisted of 2 cycles of cisplatin-based POCT followed by PORT concurrently with 2 cycles of POCT. The RT-CT protocol consisted of PORT followed by 4 cycles of cisplatin-based POCT. PORT was administered using conventional fractionation with a dose of 50.4–60 Gy. We compared the outcomes between the two adjuvant protocols and analyzed the clinical factors affecting survivals.RESULTS:
Median follow-up time was 43.9 months (range, 3.2 to 74.0 months), and the 5-year overall survival (OS), locoregional recurrence-free survival (LRFS), and distant metastasis-free survival (DMFS) were 53.9%, 68.2%, and 51.0%, respectively. There were no significant differences in OS (p = 0.074), LRFS (p = 0.094), and DMFS (p = 0.490) between the two protocols. In multivariable analyses, adjuvant protocol remained as a significant prognostic factor for LRFS, favouring CT-CCRT (hazard ratio [HR] = 3.506, p = 0.046) over RT-CT, not for OS (HR = 0.647, p = 0.229).CONCLUSION:
CT-CCRT protocol increased LRFS more than RT-CT protocol in patients with completely resected NSCLC, but not in OS. Further studies are warranted to evaluate the benefit of CCRT strategy compared with sequential strategy.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Radiotherapy
/
Follow-Up Studies
/
Chemotherapy, Adjuvant
/
Carcinoma, Non-Small-Cell Lung
/
Radiotherapy, Adjuvant
/
Drug Therapy
/
Chemoradiotherapy
Type of study:
Practice guideline
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2016
Document type:
Article