Reevaluation resection margin rectal cancer by flow cytometry and pathological examination / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 226-229, 2007.
Article
in Zh
| WPRIM
| ID: wpr-336470
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the appropriate distal resection margin in rectal cancer patients.</p><p><b>METHODS</b>Thirty specimens of rectal carcinoma with total mesorectal excision(TME) were studied by flow cytometry and pathological examination. The differences of DNA ploidy status, DNA index (DI), proliferative index (PI), S-phase fraction (SPF) among rectal cancer, 3 cm and 5 cm below the tumor, normal rectum, distal mesorectum 3 cm and 5 cm below the tumor, and normal colon mesentery were analysed by flow cytometry, and were compared with the data of pathological examination.</p><p><b>RESULTS</b>Pathological examination showed that there was no tumor invasion 3 cm and 5 cm below the tumor,but the metastasis rates of distal mesorectum 3 cm and 5 cm below the tumor were 26.7% and 6.7% respectively. The DI, PI and SPF of rectal cancer by flow cytometric examination were significantly higher than those of distal rectum 3 cm and 5 cm below the tumor, and normal rectum (P<0.05). The DI, PI and SPF of distal rectum 3 cm below the tumor were also significantly higher than those of distal rectum 5 cm below the tumor, and normal rectum (P<0.05), but there were no significant differences between DI, PI and SPF of distal rectum 5 cm below the tumor and those of normal rectum (P>0.05). The rate of DNA aneuploid of tumor was significantly higher than those of normal rectum and distal rectum 5 cm below the tumor,but there was no significant difference between the rate of DNA aneuploid of tumor and that of distal rectum 3 cm below the tumor. The DI and DNA aneuploid of rectal cancer and distal mesorectum 3 cm and 5 cm below the tumor were significantly higher than those of normal mesorectum,but there were no significant differences between DI and DNA aneuploid of rectal cancer and those of distal mesorectum 3 cm and 5 cm below the tumor. The PI and SPF of rectal cancer were significantly higher than those of normal mesorectum and distal mesorectum 3 cm and 5 cm below the tumor.</p><p><b>CONCLUSIONS</b>Rectal cancer is able to invade distal rectum 3 cm below the tumor and distal mesorectum 5 cm below the tumor, and radical resection of rectal cancer should beyond that range.</p>
Full text:
1
Database:
WPRIM
Main subject:
Pathology
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Rectal Neoplasms
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Rectum
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General Surgery
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Treatment Outcome
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Flow Cytometry
/
Neoplasm Staging
Limits:
Adult
/
Aged
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2007
Document type:
Article