Premature atherosclerosis in patients with acquired immunodeficiency syndrome / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 3396-3399, 2010.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-336614
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Increased risk of atherosclerosis has been reported in patients with human immunodeficiency virus (HIV) infection since highly active antiretroviral therapy (HAART) has come into use. However, there is no clear evidence of premature atherosclerosis in Chinese HIV-infected patients. Our study was designed to determine the relationship between HIV infection and atherosclerosis in Chinese HIV-infected patients.</p><p><b>METHODS</b>One hundred and forty-five patients were enrolled in this study. These included 82 HIV-infected patients (41 HAART-treated and 41 antiretroviral therapy (ART) naïve patients) and 43 HIV-negative control subjects. Data on traditional cardiovascular risk factors, HIV infection parameters, and treatment regimens were collected. Pulse wave velocity (PWV) was determined using a pulse pressure analyzer to evaluate the function of the arterial wall as an indicator of atherosclerotic vascular damage.</p><p><b>RESULTS</b>A higher PWV ((1358.3 ± 117.8) cm/s vs. (1270.2 ± 189.2) cm/s, P = 0.010) was found in ART naïve HIV-infected patients compared with control subjects. However, HAART treated patients had lower PWV compared to ART naïve patients ((1283.8 ± 181.4) cm/s vs. (1358.0 ± 117.8) cm/s, P = 0.033). Multiple regression analysis revealed that age (B = 5.218, 95% confidence interval (CI) 1.420 - 9.016, P = 0.008), current smoking (B = -74.671, 95%CI -147.003 to -2.339, P = 0.043) and HAART (92.7% patients on a protease inhibitor-free regimen) (B = -169.169, 95%CI -272.508 to -65.831, P = 0.010) were associated with reduced PWV in HIV-infected patients.</p><p><b>CONCLUSIONS</b>Reduced PWV in HIV-infected Chinese patients indicates that they are more likely to develop arterial wall stiffness, possibly by atherosclerosis. A protease inhibitor-free regime may be protective for arterial wall of HIV infected patients.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
Health problem:
Target 3.3: End transmission of communicable diseases
Database:
WPRIM (Western Pacific)
Main subject:
Pulsatile Flow
/
Regression Analysis
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Acquired Immunodeficiency Syndrome
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Antiretroviral Therapy, Highly Active
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Drug Therapy
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Atherosclerosis
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Vascular Stiffness
Type of study:
Diagnostic study
/
Risk factors
Limits:
Adult
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Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2010
Document type:
Article