A case-control study on risk factors of female breast cancer in Zhejiang province / 浙江大学学报·医学版

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the risk factors on female breast cancer in Zhejiang province.</p><p><b>METHODS</b>A case-control study was conducted in 200 cases of female breast cancer with histopathological diagnosis and 200 matched controls from Zhejiang province.</p><p><b>RESULTS</b>Univariate conditional logistic regression showed that family history of malignant tumor and breast cancer, housing decoration in last 10 years, mammary hyperplasia, adverse life events, bra with steel rings, sleeping with bra, high fat and pickle intake, poor sleep were positively related to breast cancer; whereas environmental friendly decoration materials, long decoration time interval, workplace condition, more lactation and parity, high fruits intake, sufficient sleep were negatively related to breast cancer. Multivariate conditional logistic regression analysis showed that the risk factors included family history of other tumors [odds ratio (OR)= 1.571,95% confidence interval(CI)1.029-2.396],mammary hyperplasia (OR=3.066,95%CI1.834-5.126), job-related life events (OR=4.575,95%CI1.690-12.390),the death of a loved one (OR=2.555,95%CI1.475-4.424), wearing bra at night (OR=1.902,95%CI1.177-3.072),high fat intake (OR=2.709,95%CI1.546-4.749) and salted food (OR=2.460,95%CI1.300-4.653). Factors as environmental friendly decoration materials (OR=0.517,95%CI0.339-0.789),workplaces condition (OR=0.430,95%CI0.243-0.762),more lactation (OR=0.109,95%CI0.013-0.896),enough sleep (OR=0.424,95%CI0.205-0.880) were protective factors.</p><p><b>CONCLUSION</b>Hereditary,psychological factors,lifestyle,environment and diet related factors are significantly associated with risk of breast cancer.</p>