Nrf2 as a chemoprevention target in gastrointestinal carcinoma / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 453-463, 2012.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-336768
Responsible library:
WPRO
ABSTRACT
Gastrointestinal tract carcinoma is one of the leading causes of cancer-related death in China. Chemoprevention has been considered as a potential approach to control this type of disease. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that protects cells from oxidative/electrophilic stresses by activating the expression of a battery of cytoprotective genes through the antioxidant response element (ARE). Recently, Nrf2 has emerged as a novel target for chemoprevention. Several natural or synthetic chemicals, which activate Nrf2/ARE signaling pathway, have showed effect in animal models, and promises in many ongoing clinical trials. This review summarizes the recent findings on the regulation of Nrf2/ARE signaling pathway, and the developments in both preclinical and clinical studies.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Signal Transduction
/
Anticarcinogenic Agents
/
Oxidative Stress
/
Chemoprevention
/
Response Elements
/
Digestive System Neoplasms
/
NF-E2-Related Factor 2
/
Genetics
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2012
Document type:
Article