HLA class I alleles and haplotypes in Chinese patients with primary biliary cirrhosis / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 904-909, 2014.
Article
in Zh
| WPRIM
| ID: wpr-337067
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the HLA class I alleles and haplotypes in Chinese patients with primary biliary cirrhosis (PBC).</p><p><b>METHODS</b>Sequencing based typing-polymerase chain reaction (SBT-PCR) was used to investigate the HLA class I alleles of 146 PBC patients and 500 normal controls in northern China. The frequencies of alleles and haplotypes were calculated and compared for the two groups. The chi-square test and Fisher's exact test were used for statistical analyses.</p><p><b>RESULTS</b>There were 26, 51 and 21 alleles identified at the HLA-A, B and C loci respectively, and the frequencies of these alleles were not significantly different between the PBC and normal control groups.However, the frequencies of A *11:01-B*40:06 and A*02:01-B*l5:01 haplotypes were significantly higher in the PBC group than in the normal control group (7.53% vs. 1.40%, P<0.01, OR=5.38; 6.85% vs. 2.00%, P=0.003, OR=3.425).</p><p><b>CONCLUSION</b>This study established the role of HLA class I haplotypes in determining PBC susceptibility in a Chinese population.</p>
Full text:
1
Database:
WPRIM
Main subject:
Haplotypes
/
Histocompatibility Antigens Class I
/
China
/
Polymerase Chain Reaction
/
Asian People
/
Alleles
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Gene Frequency
/
Liver Cirrhosis, Biliary
Limits:
Humans
Country/Region as subject:
Asia
Language:
Zh
Journal:
Chinese Journal of Hepatology
Year:
2014
Document type:
Article