Immunophenotypic characteristics of multiple myeloma cells / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 226-228, 2002.
Article
in Zh
| WPRIM
| ID: wpr-337604
Responsible library:
WPRO
ABSTRACT
To investigate the immunophenotypic characteristics of multiple myeloma (MM) cells, 20 bone marrow samples from patients with multiple myeloma were analyzed by flow cytometry with three-color direct immunofluorescence staining. Results showed that all of myeloma cells expressed bright CD38, dim or negative CD45 and negative CD19. Most of the cells were CD56(+) and a small portions were ckappa(+) or clambda(+), or CD20(+). The phenotypes of normal plasmocyte, CD19(+) and CD56(-), except CD56(-) in one-third samples, were not appeared in all detected samples. It was concluded that the surface marker analysis of myeloma cells is a useful tool for diagnosis and further evaluating prognosis of multiple myeloma.
Full text:
1
Database:
WPRIM
Main subject:
Bone Marrow Cells
/
Membrane Glycoproteins
/
Antigens, CD
/
Immunophenotyping
/
Leukocyte Common Antigens
/
CD56 Antigen
/
Antigens, CD20
/
Antigens, CD19
/
ADP-ribosyl Cyclase
/
Allergy and Immunology
Type of study:
Prognostic_studies
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2002
Document type:
Article