Change of telomerase activity in bone marrow cells from chronic myeloid leukemia patients in different phases / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 307-309, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-337632
Responsible library:
WPRO
ABSTRACT
To study the telomerase activity change in patients with CML different phases, telomerase PCR-ELISA method was used. Results showed that telomerase activity of normal bone marrow cells was low. The telomerase activity in CML at any phase was higher than that in normal bone marrow (P < 0.05). The telomerase activity in accelerated and acute transformation phases was higher than that in chronic phase (P < 0.05), but there was no significant difference between accelerated phase and acute transformation phase. It was concluded that telomerase activity could be used as an useful marker for evaluating development of course and curative effect of CML.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Bone Marrow Cells
/
Biomarkers
/
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
/
Telomerase
/
Metabolism
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2002
Document type:
Article