Your browser doesn't support javascript.
loading
EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer
Article in English | WPRIM (Western Pacific) | ID: wpr-33788
Responsible library: WPRO
ABSTRACT
A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs.
Subject(s)

Full text: Available Database: WPRIM (Western Pacific) Main subject: Base Sequence / Introns / Adenocarcinoma / Smoking / Oncogene Proteins, Fusion / Exons / Sequence Analysis, RNA / Carcinoma, Non-Small-Cell Lung / Asian People / Republic of Korea Type of study: Prognostic study Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2012 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Base Sequence / Introns / Adenocarcinoma / Smoking / Oncogene Proteins, Fusion / Exons / Sequence Analysis, RNA / Carcinoma, Non-Small-Cell Lung / Asian People / Republic of Korea Type of study: Prognostic study Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: Journal of Korean Medical Science Year: 2012 Document type: Article
...