Investigation of diagnosis and treatment for primary central nervous system lymphoma / 中华外科杂志
Chinese Journal of Surgery
; (12): 1549-1552, 2007.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-338114
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the clinical characteristics of primary central nervous system lymphoma (PCNSL) so as to improve comprehension of that unusual lesions.</p><p><b>METHODS</b>Forty-three cases of immunocompetent patients with a confirmed diagnosis of PCNSL were retrospectively reviewed. The clinical presentation, laboratory examination, imaging characteristics, histopathologic types and treatment were analyzed.</p><p><b>RESULTS</b>Single-locus lesion was found in thirty-six patients and multi-locus lesions were found in seven patients. Forty-seven operations were performed. The main characteristics including increased intracranial pressure in 22 cases (51.2%) followed by hemiparesis, seizure and speech problems in 16 cases (37.2%), disturbance of intellectual function and mental confusion in 10 cases (23.3%), contents of cerebrospinal fluid protein concentrations increased in 8 of 12 tested cases (66.7%). Histopathologic exam showed B-cell lymphoma in 40 (40/41, 97.6%) and T-cell lymphoma in 1 case (1/41, 2.4%). Ki-67 positive expression is 42.8% +/- 23.3% in 3 samples.</p><p><b>CONCLUSIONS</b>CT, MRI and CSF cytological examination are mainly diagnostic methods for PCNSL. Elevated lymphocyte counting in peripheral blood can not be the diagnostic criteria for PCNSL. The purpose of operation is alleviating symptom, increasing quantity of life and making histopathologic diagnosis. Adjuvant chemotherapy plus whole-brain radiation is an efficient treatment for PCNSL.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Therapeutics
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Lymphoma, Non-Hodgkin
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Immunohistochemistry
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Retrospective Studies
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Follow-Up Studies
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Central Nervous System Neoplasms
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Ki-67 Antigen
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Diagnosis
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Metabolism
Type of study:
Diagnostic study
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Observational study
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Prognostic study
Limits:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2007
Document type:
Article