Intestinal inflammation-induced child growth failure: immunologic and endocrine mechanisms / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 767-771, 2011.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-339536
Responsible library:
WPRO
ABSTRACT
Faltering linear growth is commonly encountered in children with intestinal inflammation. Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are important regulators of postnatal longitudinal bone growth. Inhibition of GH/IGF axis will result in growth failure in young children. Pro-inflammatory cytokines such as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) abnormally increase in children with intestinal inflammation, and may affect linear growth both systemically and locally at the level of the growth plate though disturbing the GH/IGF axis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Bone Development
/
Somatomedins
/
Cytokines
/
Human Growth Hormone
/
Enteritis
/
Growth Disorders
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2011
Document type:
Article