Association between interleukin-1β C+3953T and genetic susceptibility to spontaneous preterm birth: a case-control study / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1123-1129, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-340554
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between interleukin-1β (IL-1β) C+3953T and genetic susceptibility to spontaneous preterm birth (SPTB).</p><p><b>METHODS</b>In this case-control study, 753 SPTB neonates were enrolled in the case group and 681 full-term neonates were enrolled in the control group. The latest Sequenom MassARRAY®SNP detection technique was used for the typing of single nucleotide polymorphisms (SNP) of IL-1β C+3953T.</p><p><b>RESULTS</b>Compared with those carrying CC genotype of IL-1β C+3953T, the neonates who carried at least one T allele (CT+TT genotype) had significantly increased risks of SPTB, SPTB complicated by premature rupture of membranes, and mild preterm birth.</p><p><b>CONCLUSIONS</b>In the Chinese population, IL-1β C+3953T has significant genetic association with an increased risk of SPTB. The identification of this SNP helps to prevent SPTB and clarify the causes and pathogenesis of SPTB.</p>
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 9: Noncommunicable diseases and mental health
Database:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Premature Birth
/
Interleukin-1beta
/
Genetics
Type of study:
Observational study
/
Risk factors
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Document type:
Article