Changes in serum cortisol and adrenocorticotropic hormone in children with sepsis shock and their clinical significance / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1009-1012, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-340576
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes in serum levels of cortisol and adrenocorticotropic hormone (ACTH) in children with septic shock (SS) and to explore their relationship with the disease severity and prognosis.</p><p><b>METHODS</b>Twenty-five children with decompensated SS and 24 children with early SS were enrolled. Serum cortisol and ACTH levels were determined on admission and days 3 and 8 after admission. Twenty-five healthy children were used as the control group. The children with decompensated SS were further divided into death group (n=5) and survival group (n=20) based on their clinical outcome.</p><p><b>RESULTS</b>On admission, the decompensated SS and early SS groups had significantly higher serum cortisol and ACTH levels than the control group (P<0.05), and the decompensated SS group had significantly higher serum cortisol and ACTH levels than the early SS group. On day 3 after admission, the decompensated SS group had significantly higher serum cortisol and ACTH levels than the early SS and control groups (P<0.05), and the early SS group had a significantly higher serum ACTH level than the control group (P<0.05). Among the children with decompensated SS, the death group had significantly higher serum cortisol and ACTH levels than the survival group on admission (P<0.01); on day 3 after admission, the death group still had a significantly higher serum cortisol level than the survival group (P<0.01).</p><p><b>CONCLUSIONS</b>Children with SS have increased serum cortisol and ACTH levels, which are associated with the disease severity. A persistent high serum cortisol level indicates a poor prognosis. Dynamic monitoring of serum cortisol and ACTH levels in children with SS is of great significance in evaluating the disease severity and prognosis.</p>
Full text:
Available
Health context:
SDG3 - Health and Well-Being
/
SDG3 - Target 3.3 End transmission of communicable diseases
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SDG3 - Target 3.2 Reduce avoidable death in newborns and children under 5
Health problem:
Target 3.2: Reduce avoidable death in newborns and children under 5
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Sepsis
/
Infections
Database:
WPRIM (Western Pacific)
Main subject:
Shock, Septic
/
Blood
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Hydrocortisone
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Mortality
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Adrenocorticotropic Hormone
Type of study:
Prognostic study
Limits:
Child, preschool
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Female
/
Humans
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Infant
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Document type:
Article