Immunological mechanism of wheezing attack in children with cytomegalovirus infection / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 831-834, 2016.
Article
in Zh
| WPRIM
| ID: wpr-340610
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the possible immunological mechanism of wheezing attack in children with cytomegalovirus (CMV) infection.</p><p><b>METHODS</b>A total of 25 under-5-year-old children with wheezing following CMV infection were enrolled. The expression of serum regulatory T cells (Treg)/T helper 17 (Th17) cytokines interleukin (IL)-10, IL-6, and IL-17, and peripheral blood lymphocyte subsets were determined. Twenty age-matched healthy children were selected as the control group.</p><p><b>RESULTS</b>The wheezing group had a significantly reduced serum IL-10 level, significantly increased IL-6 and IL-17 levels, significantly reduced levels of natural killer cells, and significantly increased levels of CD8+ T cells and CD19+ B cells, as compared with the control group.</p><p><b>CONCLUSIONS</b>Wheezing children with CMV infection have Treg/Th17 imbalance and cellular immune dysfunction, which may be an important immunological mechanism of the development of wheezing in children after CMV infection.</p>
Full text:
1
Database:
WPRIM
Main subject:
Blood
/
Respiratory Sounds
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Cytokines
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T-Lymphocytes, Regulatory
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Cytomegalovirus Infections
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Allergy and Immunology
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Th17 Cells
Limits:
Child, preschool
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Female
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Humans
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Infant
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Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2016
Document type:
Article