Relationship between paraoxonase/glutathione S-transferase gene polymorphism and health conditions of floriculture farmers / 中华流行病学杂志

ABSTRACT

Objective In this study we conducted a cross-sectional study and reported on the distribution of two common genetic polymorphisms of the PON1 gene and two common genetic polymorphisms of the GST gene as well as the association between those polymorphisms and other predictors in a population of floriculture workers from Kunming city. Methods 136 pesticide-exposed farmers were recruited. PON1 and GST T1, M1 genotype were determined by means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results (1)Compared with exposure group, the GLB in control group was higher(β=-0.16,t=-2.30, P=0.02), but the A/G in control group was lower (β=0.14,t=2.09,P=0.04); (2) Compared with the persons who carried QQ genotype, the accumulative symptom scores were lower in the persons who carried RR genotype(t=-2.78, P=0.006); (3) Compared with GST T1 carriers, non-carriers' GLB (β=-0.20, t=-3.01, P=0.00)and IgG(β=-0.20,t=-3.01, P=0.00)were higher, but the A/G was lower; (4) The abnormities of cardiograms among people who had been exposed to pesticides were higher compared to people who did not expose to any pesticides (β=1.147, P=0.042). Conclusion PON1-192 and GST T1 gene were associated with the farmers health condition after pesticides exposure.