Vasculogenic mimicry and mosaic vessels and targeted therapy in renal cell carcinoma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 462-467, 2011.
Article
in Zh
| WPRIM
| ID: wpr-341384
Responsible library:
WPRO
ABSTRACT
Renal cell carcinoma is one of the most common malignant tumors of urinary system. The annual incidence rate is approximately 17.9/100 000 populations, and there is a continually rising trend in number of new diagnosis. Metastatic and high-risk renal cell cancer is associated with a poor prognosis and is resistant to traditional chemotherapy and/or radiotherapy. Although cytokine-based therapies (interferon and interleukin-2) have been widely used, their effectiveness remained unsatisfactory due to their low response rates and short survival. Drugs targeting anti-angiogenesis pathways have shown benefits in relapse-free survival. In this review, we introduce the recent advances in the treatment of renal cancer, especially the application of vasculogenic mimicry and mosaic vessels. Although targeted therapies with anti-angiogenic properties have proposed new treatment criteria for advanced renal cell carcinoma, new drugs or new combinations are needed to improve the clinical efficacy and minimize adverse effects.
Full text:
1
Database:
WPRIM
Main subject:
Therapeutics
/
Carcinoma, Renal Cell
/
Kidney Neoplasms
Type of study:
Prognostic_studies
Limits:
Humans
Language:
Zh
Journal:
Acta Academiae Medicinae Sinicae
Year:
2011
Document type:
Article