Influence of lyophilized Radix Astragali powder injection on hemodynamics of dogs with myocardial ischemia / 生物医学工程学杂志

ABSTRACT

In order to observe the influence of lyophilized Radix Astragali powder injection on hemodynamics and myocardial consumption of oxygen of dogs with myocardial ischemia, we establised the myocardial ischemia model by ligating the anterior descending branch of left coronary artery of 5 mongrel dogs. Then the drugs were administered intravenously, and the hemodynamic parameters and myocardial consumption of oxygen of the dogs were measured. All the Radix Astragali groups and Radix Salviae Miltiorrhizae Group (RSMG) showed significantly decreased heart rate (HR), diastolic blood pressure (DBP), mean arterial pressure (MAP) of dogs with myocardial ischemia in 5-30 min after drug administration (P < 0.05-0.01). All the Radix Astragali groups and the RSMG showed significantly lowered left ventricular end-diastolic pressure (LVEDP) of the dogs in 10 min-4 h after drug administration (P < 0.05-0.01). All the Radix Astragali groups displayed significantly increased maximum contraction velocity (+dp/dt(max)) of the dogs in 10 min after drug administration (P < 0.05-0.01). All the Radix Astragali groups and the RSMG displayed significantly increased cardiac output (CO) in 10 min-4 h after drug administration, in which the High Dose Group (HDG) of Radix Astragali displayed the highest statistical significance (P < 0.01). All the Radix Astragali groups and the RSMG exhibited significantly decreased peripheral resistance (TPR) and increased coronary blood flow (CBF) in 10 min-4 h after drug administration (P < 0.05-0.01). HDG showed significantly decreased myocardial work (MW) in 5 min-30 min after drug administration (P < 0.05-0.01). HDG and MDG exhibited significantly decreased oxygen uptake rate of the myocardium (MVo2) in 30 min-3 h after drug administration(P < 0.05-0.01). In summary, the lyophilized Radix Astragali powder injection can significantly benefit all the indexes and strengthen the heart function of the dogs with myocardial ischemia.