Intermittent hypoxia with or without hypercapnia is associated with tumorigenesis by decreasing the expression of brain derived neurotrophic factor and miR-34a in rats / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 43-47, 2014.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-341717
Responsible library:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Very recent studies revealed that obstructive sleep apnoea (OSA) is a contributor of the increased incidence and mortality of cancer in humans, but mechanisms of how OSA promotes tumorigenesis remains largely unknown. We investigated whether intermittent hypoxia with and without hypercapnia plays a role in tumorigenesis.</p><p><b>METHODS</b>First, Sprague-Dawley (SD) male rats (12 weeks old) were subjected to different hypoxia exposures intermittent hypoxia and intermittent hypoxia with hypercapnia; continuous hypoxia and normal air. The systemic application of chronic fast rate hypoxia with or without hypercapnia mimicked severe OSA patients with apnoea/hypopnea index equivalent to 60 events per hour. Then routine blood tests were performed and the levels of brain derived neurotrophic factor (BDNF) and miR-34a were examined.</p><p><b>RESULTS</b>In contrast to intermittent hypoxia with hypercapnia, both intermittent hypoxia and continuous hypoxia treatments caused significantly higher levels of haematology parameters than normoxia treatments. Compared to normoxia, intermittent hypoxia with hypercapnia exposure resulted in substantial decrease of serum BDNF and, miR-34a in the lower brainstem, while less pronounced results were found in intermittent hypoxia and continuous hypoxia exposure.</p><p><b>CONCLUSIONS</b>The exposure of intermittent hypoxia with or without hypercapnia, mimicking the situations in severe OSA patients, was associated with, or even promoted tumorigenesis.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Brain and Nervous System Cancers
Database:
WPRIM (Western Pacific)
Main subject:
Blood
/
Brain Stem
/
Cell Transformation, Neoplastic
/
Rats, Sprague-Dawley
/
Brain-Derived Neurotrophic Factor
/
MicroRNAs
/
Real-Time Polymerase Chain Reaction
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Hypercapnia
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Hypoxia
/
Metabolism
Limits:
Animals
Language:
English
Journal:
Chinese Medical Journal
Year:
2014
Document type:
Article