A Case of Sunitinib-Associated Thrombotic Thrombocytopenic Purpura / 대한내과학회지
Korean Journal of Medicine
; : 303-307, 2013.
Article
in Korean
| WPRIM (Western Pacific)
| ID: wpr-34182
Responsible library:
WPRO
ABSTRACT
Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP-HUS) is an acute condition with abnormalities of multiple organ systems. It is characterized by microangiopathic hemolytic anemia and thrombocytopenia. Several chemotherapeutic agents have been implicated in causing TTP-HUS. We report a case of TTP-HUS during treatment with sunitinib in a patient with metastatic renal cell carcinoma. A 53-year-old woman visited our hospital for fever and cough. She was diagnosed with sunitinib-induced TTP. Discontinuation of sunitinib and plasmapheresis improved her TTP. When she experienced disease progression after a prolonged period without treatment, sorafenib was tried, resulting in a partial response without recurrence of TTP-HUS.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Phenylurea Compounds
/
Purpura, Thrombotic Thrombocytopenic
/
Pyrroles
/
Recurrence
/
Thrombocytopenia
/
Thymine Nucleotides
/
Carcinoma, Renal Cell
/
Plasmapheresis
/
Niacinamide
/
Disease Progression
Limits:
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2013
Document type:
Article