Maternal Stress and Depressive Symptoms and Infant Development at Six Months: the Mothers and Children's Environmental Health (MOCEH) Prospective Study
Journal of Korean Medical Science
; : 843-851, 2016.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-34239
Responsible library:
WPRO
ABSTRACT
Our objective is to evaluate the relationships between prenatal maternal stress and depressive symptoms, respectively, and infant neurodevelopment at 6 months, adjusted for heavy metals and oxidative stress. This research is a part of a multi-center birth cohort study in South Korea. Information on stress and depressive symptoms was collected during the first trimester using Psychosocial Well-Being Index Short Form (PWI-SF) and Center for Epidemiological Studies Depression Scale (CES-D). The Korean Bayley Scales of Infant Development-II assessment (BSID-II), which includes the standardized mental development index (MDI) and psychomotor developmental index (PDI), and Korean Ages & Stages Questionnaires (K-ASQ) were applied to infants at six months of age. A higher index score indicates better development. Among 641 babies, 320 were female (50%). Maternal PWI ≥ 29 (vs. PWI ≤ 18) during early pregnancy was associated with a decrease in MDI scores of 5.37 points (P = 0.02) after adjusting for socioeconomic factors. Maternal CES-D ≥ 26 (vs. CES-D ≤ 10) during early pregnancy was associated with a decrease in MDI scores of 8.18 points (P = 0.01). The associations remained significant even after adjustment for lead, cadmium, and MDA levels (P < 0.05). However, no association was found between maternal PWI/CES-D and PDI score. No interaction was observed between stress and lead exposure. We found an inverse association between prenatal maternal stress and depressive symptoms, and MDI scores in 6-month-old infants after adjustment for prenatal lead exposure, which is known to affect cognitive function negatively.
Full text:
Available
Health context:
Sustainable Health Agenda for the Americas
Health problem:
Goal 11: Inequalities and inequities in health
Database:
WPRIM (Western Pacific)
Main subject:
Stress, Psychological
/
Cadmium
/
Linear Models
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Child Development
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Prospective Studies
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Surveys and Questionnaires
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Cohort Studies
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Depression
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Lead
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Malondialdehyde
Type of study:
Controlled clinical trial
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Diagnostic study
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Etiology study
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Incidence study
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Observational study
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Prognostic study
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Qualitative research
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Risk factors
Aspects:
Equity and inequality
Limits:
Adult
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Female
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Humans
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Infant
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Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2016
Document type:
Article