Preparation and degradation behavior of PELGE nanoparticles / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 921-925, 2004.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-342579
Responsible library:
WPRO
ABSTRACT
A series of poly (lacticacid-co-glycolicacid)-poly(ethylene glycol) (PLGA-PEG, PELGA) block copolymers and poly (ethylene glycol)-poly (lacticacid-co-glycolicacid)-poly (ethylene-glycol) (PELGE) was synthesized by ring-opening polymerization. PELGA nanoparticles and PELGE nanoparticles were prepared using the emulsion-solvent evaporation technique (O/W). To study the behavior and mechanism of the degradation of PELGA-NP and PELGA-NP, we determined the lactic acids by UV spectrophotometry. The method confirmed that degradation was much faster for polymers with a decrease in the LA content of the polymers or an increase in the PEG content of the polymers.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Polyesters
/
Polyethylene Glycols
/
Polyglactin 910
/
Polyglycolic Acid
/
Polymers
/
Biocompatible Materials
/
Biodegradation, Environmental
/
Drug Carriers
/
Chemistry
/
Drug Delivery Systems
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2004
Document type:
Article