Arterial blood gas analysis in Lipopolysaccharide-heat co-stressed rats / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 164-166, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-343029
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the change in vital signs and arterial blood gas in Lipopolysaccharide (LPS)-injected heat exposed rats.</p><p><b>METHODS</b>Male pathogen-free Wistar rats were randomly assigned to the following groups saline-injected normothermic control (C-Group), saline-injected heat exposed (H-Group), LPS-injected normothermic control (L-Group), LPS-injected heat exposed (HL-Group). Rectal temperature (Tr), heart rate (HR), mean arterial pressure (MAP), arterial blood gas were continually monitored.</p><p><b>RESULTS</b>(1) The rats in HL-Group displayed significantly high values of Tr (43.04 degrees C +/- 0.11 degrees C) and HR [(660 +/- 42) beats/min] and low values of MAP [(49.0 +/- 3.5) mm Hg] compared with C-Group. There was a significant difference in the values of Tr, HR, and MAP between HL-Group and L-Group and in the values of HR and MAP between HL-Group and H-Group. (2) The values of PaO(2), HCO(3)(-), PaCO(2) were significantly lower than those in C-Group at 40 min after LPS-injected heat stress. At 120 min, the PaO(2) [(11.59 +/- 1.11) kPa], HCO(3)(-) [(10.42 +/- 1.06) mmol/L], PaCO(2) [(2.82 +/- 0.81) kPa] in HL-Group were significantly lower than those in L-Group. A significant difference in the values of HCO(3)(-) and PaCO(2) between HL-Group and H-Group was also observed.</p><p><b>CONCLUSION</b>LPS-injected heat stress primes the rat to advance and augment the change in vital signs, arterial blood gas, and systemic inflammatory response syndrome.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
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Blood
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Blood Gas Analysis
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Blood Pressure
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Body Temperature
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Random Allocation
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Lipopolysaccharides
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Rats, Wistar
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Heat Stress Disorders
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Toxicity
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Year:
2006
Document type:
Article