Effects of experimental varicocele on the apoptosis of epididymis epithelium and synthesizing function of the epididymis in rats / 中华男科学杂志
National Journal of Andrology
; (12): 619-621, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-343559
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationships of experimental varicocele to the apoptosis of epididymis epithelium and changes of the contents of alpha-1,4-glucosidase and sialic acid from the unilateral epididymis in adolescent rats, and to investigate the effects of varicocele on the unilateral epididymis epithelium.</p><p><b>METHODS</b>Experimental left varicocele models of 16 adult male Sprague-Dawley rats were obtained by partial ligation of the left renal vein. The epididymides were collected for detecting the apoptosis of epididymis epithelium and the contents of alpha-1,4-glucosidase and sialic acid by using spectrophotometry.</p><p><b>RESULTS</b>Seven days after the establishment of the left varicocele model, the index of the apoptosis of the left epididymis epithelium was significantly higher (P < 0.001) and the contents of alpha-1,4-glucosidase and sialic acid significantly lower (P < 0.05, P < 0.005) in the experimental group than in the control.</p><p><b>CONCLUSION</b>The results suggest that unilateral varicocele may increase the apoptosis of epididymis epithelium and the contents of alpha-1,4-glucosidase and sialic acid and subsequently affect the synthesizing and secretory function of the epididymis.</p>
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Cardiovascular Disease
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Varicocele
/
Rats, Sprague-Dawley
/
Apoptosis
/
N-Acetylneuraminic Acid
/
Epididymis
/
Epithelium
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Alpha-Glucosidases
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2006
Document type:
Article