Sexual hormone levels in semen and germ cell apoptosis / 中华男科学杂志
National Journal of Andrology
; (12): 432-434, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-343604
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between sexual hormones in semen and germ cell apoptosis in male population.</p><p><b>METHODS</b>Sixty-six infertile patients and thirty fertile males were selected randomly. The levels of folicle stimulating hormone ( FSH), prolactin (PRL), luteinizing hormone (LH), and testosterone (T) in semen were measured by ELISA. Terminal deoxynucleotidyl transferase mediated UTP nick end labeling (TUNEL) was used for the detection of germ cell apoptosis.</p><p><b>RESULTS</b>The levels of FSH, LH, PRL, T in thirty fertile men were (1.63 +/- 0.15) U/L, (2.18 +/- 0.21) U/L, (6.34 +/- 0.30) nmol/L, (1.85 +/- 0.11) nmol/L, respectively, and germ cell apoptosis rate was (4.61 +/- 1.23)%. FSH, LH, PRL, T levels in infertile group were (1.25 +/- 0.18) U/L, (1.76 +/- 0.32) U/L, (5.86 +/- 0.13) nmol/l, (1.45 +/- 0.13) nmol/, respectively, and germ cell apoptosis rate was (18.36 +/- 2.04)%. There were significant differences in all parameters between infertile group and fertile group. The levels of FSH, LH, PRL, T were negatively correlated with germ cell apoptosis rates( r = -0.88, -0.93, -0.90, -0.98). The volume of apoptotic germ cell decreased, and chromatin was compacted to form cell-membrane blebs and apoptotic bodies.</p><p><b>CONCLUSION</b>Low concentration of sexual hormones may increase the apoptosis of germ cells, which can induce male infertility.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prolactin
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Semen
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Gonadal Steroid Hormones
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Testosterone
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Luteinizing Hormone
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Case-Control Studies
/
Apoptosis
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Follicle Stimulating Hormone
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Germ Cells
Type of study:
Observational study
Limits:
Adult
/
Humans
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Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2006
Document type:
Article