Predictive value of serum inhibin B levels as an indicator of the presence of testicular spermatozoa in nonobstructive azoospermia / 中华男科学杂志
National Journal of Andrology
; (12): 410-412, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-343610
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the predictive value of serum inhibin B (INH B) levels as an indicator of the presence of testicular spermatozoa in nonobstructive azoospermia.</p><p><b>METHODS</b>Forty patients with nonobstructive azoospermia (NOA), 20 patients with obstructive azoospermia (OA), and 10 fertile volunteers were involved in this study. A chemoluminescence method was used to measure the levels of FSH; Inhibin B was analysed by using sandwich enzyme-linked immuno-sorbent assay.</p><p><b>RESULTS</b>Patients with nonobstructive azoospermia has significantly higher levels of serum FSH [(21.34 +/- 12.15) IU/L] and significantly lower levels of inhibin B [(53.15 +/- 58.74) ng/L] than patients with obstructive azoospermia [FSH (3.94 +/- 1.52) IU/L, INH B (162.49 +/- 78.38) ng/L, P < 0.01] and fertile volunteers [FSH (4.27 +/- 2.84) IU/L, INH B (228.49 +/- 110.68) ng/L, P < 0.01]. Mean serum inhibin B were significantly higher in patients with nonobstructive azoospermia who had spermatozoa on TESE than in those in whom no spermatozoa was found on TESE [INHB (90.31 +/- 72.18) ng/L vs (19.54 +/- 20.38) ng/L, r = 0.528, P < 0.01], but mean FSH levels did not have similar predictive power (P > 0.05).</p><p><b>CONCLUSION</b>Serum INH B level seems to be more accurate than serum FSH in the prediction of presence of testicular spermatozoa in patients with nonobstructive azoospermia. Serum inhibin B determination may be substitute of TESE as a diagnostic index.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Spermatozoa
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General Surgery
/
Testis
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Blood
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Enzyme-Linked Immunosorbent Assay
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Case-Control Studies
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Predictive Value of Tests
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Diagnosis
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Azoospermia
Type of study:
Diagnostic study
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Observational study
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Prognostic study
/
Risk factors
Limits:
Adult
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Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2006
Document type:
Article