Prevalence and Prognostic Implication of Non-Calcified Plaque in Asymptomatic Population with Coronary Artery Calcium Score of Zero
Korean Circulation Journal
; : 154-160, 2013.
Article
in English
| WPRIM (Western Pacific)
| ID: wpr-34371
Responsible library:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
Non-calcified plaque (NCP) identified by coronary CT angiography (CCTA) has been reported in up to 10% of individuals with coronary artery calcium score (CACS) of zero. However, clinical risk factors and the prognostic value of NCP in asymptomatic subjects with CACS of zero are unknown. SUBJECTS ANDMETHODS:
The study population consisted of consecutive asymptomatic subjects (48+/-8 years, 57% men) who underwent CCTA from December 2005 to January 2008 as part of a general health evaluation.RESULTS:
Among 4491 of overall asymptomatic individuals with CACS of zero, 313 subjects (7%) had NCP 279 patients (6%) with non-obstructive and 34 (1%) with obstructive. In multivariable analyses, age, male gender, diabetes, hypertension, and dyslipidemia were significantly associated with presence of NCP (all p<0.05). During the median follow-up duration of 22 months (interquartile percentile 18 to 28 months) of subjects with NCP (n=313) and age, gender, and CCTA date matched individuals without NCP (n=313), there was no clinical event including all-cause death nor composite outcome of cardiac death, myocardial infarct, unstable angina requiring hospitalization, and revascularization after 90 days from index CCTA in both groups.CONCLUSION:
In the largest series of asymptomatic individuals with CACS of zero undergoing CCTA, age, male gender, diabetes, hypertension, and dyslipidemia were independently associated with NCP. However, a future risk of exclusive NCP in asymptomatic subjects with CACS of zero was negligible.
Full text:
Available
Health context:
SDG3 - Target 3.4 Reduce premature mortality due to noncommunicable diseases
Health problem:
Arterial Hypertension
/
Cardiovascular Disease
/
Endocrine System Diseases
/
Ischemic Heart Disease
Database:
WPRIM (Western Pacific)
Main subject:
Angiography
/
Calcium
/
Prevalence
/
Risk Factors
/
Follow-Up Studies
/
Coronary Vessels
/
Death
/
Dyslipidemias
/
Plaque, Atherosclerotic
/
Hospitalization
Type of study:
Etiology study
/
Observational study
/
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Korean Circulation Journal
Year:
2013
Document type:
Article