Synthesis and in vitro cytotoxicity of naphthalimide polyamine conjugates as antitumor agents / 药学学报
Acta Pharmaceutica Sinica
; (12): 754-757, 2009.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-344111
Responsible library:
WPRO
ABSTRACT
Six naphthalimide polyamine conjugates were synthesized and their structures were confirmed by elemental analysis, 1H NMR, 13C NMR and MS. Antitumor activities were evaluated in vitro using MTT assay on Leukemia cells (K562), human breast cancer cells (MB-231) and prostate cancer cells (Ln cap cell). The results showed that most of the six compounds were superior to the control (amonafide), 6d, 6e, and 6f exhibited nice selectivity in a screen of hepatoma cells (BEL-7402) and human normal hepatocytes (QSG-7701).
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Polyamines
/
Molecular Structure
/
Cell Line, Tumor
/
Naphthalimides
/
Antineoplastic Agents
Limits:
Humans
/
Male
Language:
Chinese
Journal:
Acta Pharmaceutica Sinica
Year:
2009
Document type:
Article
