Progress in genetic research on essential tremor / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 767-771, 2017.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-344178
Responsible library:
WPRO
ABSTRACT
Essential tremor (ET) is one of the most common movement disorders. Its clinical manifestations not only include typical kinetic and/or postural tremors, but also other non-motor symptoms such as cognitive dysfunction, sleep disturbance, and dysosmia. The exact etiology and pathogenesis of ET is still unknown. Approximately 60% of ET patients have a family history, and genetic factor plays an important role in the onset of the disease. Researchers have so far identified 3 genetic loci (ETM 1-3) through family studies, and proposed additional causative genes such as FUS, HTRA2, TENM4, NOS3 and susceptibility genes such as LINGO, SLC1A2, and GABA. This review focuses on the progress made in genetic research on ET.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Genetic Predisposition to Disease
/
Essential Tremor
/
RNA-Binding Protein FUS
/
Genetic Research
/
High-Temperature Requirement A Serine Peptidase 2
/
Genetics
/
Membrane Proteins
/
Nerve Tissue Proteins
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2017
Document type:
Article