Development of Silymarin nanocrystals lyophilized power applying nanosuspension technology / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To prepare silymarin nanosuspension and lyophilized power for enhancing the dissilution of poorly soluble drugs.</p><p><b>METHOD</b>The precipitation technique was adapted to produce the silymarin nanosuspensions respectivly applying Tween 80, SDS and Poloxamer188 as stabilizers. The lyophilized formula contained 5% mannitol as cryoprotectant. Particle size, Polydispersity index and Zeta potential were detected by Mastersizer nano ZS (Malvern England). Morphological character was observed with Transmission Electron Microscopy. The product's structure was performed with X-ray diffractometer.</p><p><b>RESULT</b>The silymarin nanosuspension was successfully prepared, in which the drug particle size was about 100-300 nm,and the particles had ball-like shape and good dispersive properties.</p><p><b>CONCLUSION</b>This study provided potential for the neotype dosage form development of the Chinese Traditional Medicine.</p>