COX- 2 expression in gastric cancer and its relationship with lymphangiogenesis and lymph node metastasis / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 348-351, 2005.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-345174
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor-C (VEGF-C) in human gastric cancer, the relationship between their expression and the clinicopathological features,as well as the relationship between these two parameter expression and lymphangiogenesis and lymph node metastasis.</p><p><b>METHODS</b>COX-2 and VEGF-C expressions were detected in 63 gastric cancer samples by immunostaining. Lymphangiogenesis was evaluated by immunostaining with the specific antibody LYVE-1.</p><p><b>RESULTS</b>The expression rates of COX-2 and VEGF-C were 66.7% (42/63), 52.4% (33/63), respectively in 63 gastric cancer specimens. LYVE-1 was positive in 35 cases (35/63), which indicated lymphangiogenesis in the tumors. The expression of COX-2 was significantly correlated with the expression of VEGF-C, tumor lymphangiogenesis and lymphatic metastasis (P< 0.05), however not gender, tumor size, tumor location, Lauren classification and serosa invasion (P< 0.05).</p><p><b>CONCLUSIONS</b>In gastric cancer, the expression of COX-2 is significantly associated with VEGF-C expression, lymphangiogenesis and lymphatic metastasis. COX-2 may up-regulate the expression of VEGF-C, which induces lymphangiogenesis and accordingly contributes to lymphatic metastasis.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Neoplasms
/
Vascular Endothelial Growth Factor C
/
Lymphangiogenesis
/
Cyclooxygenase 2
/
Lymph Nodes
/
Lymphatic Metastasis
/
Metabolism
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2005
Document type:
Article