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COX- 2 expression in gastric cancer and its relationship with lymphangiogenesis and lymph node metastasis / 中华胃肠外科杂志
Article in Chinese | WPRIM (Western Pacific) | ID: wpr-345174
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of cyclooxygenase-2 (COX-2) and vascular endothelial growth factor-C (VEGF-C) in human gastric cancer, the relationship between their expression and the clinicopathological features,as well as the relationship between these two parameter expression and lymphangiogenesis and lymph node metastasis.</p><p><b>METHODS</b>COX-2 and VEGF-C expressions were detected in 63 gastric cancer samples by immunostaining. Lymphangiogenesis was evaluated by immunostaining with the specific antibody LYVE-1.</p><p><b>RESULTS</b>The expression rates of COX-2 and VEGF-C were 66.7% (42/63), 52.4% (33/63), respectively in 63 gastric cancer specimens. LYVE-1 was positive in 35 cases (35/63), which indicated lymphangiogenesis in the tumors. The expression of COX-2 was significantly correlated with the expression of VEGF-C, tumor lymphangiogenesis and lymphatic metastasis (P< 0.05), however not gender, tumor size, tumor location, Lauren classification and serosa invasion (P< 0.05).</p><p><b>CONCLUSIONS</b>In gastric cancer, the expression of COX-2 is significantly associated with VEGF-C expression, lymphangiogenesis and lymphatic metastasis. COX-2 may up-regulate the expression of VEGF-C, which induces lymphangiogenesis and accordingly contributes to lymphatic metastasis.</p>
Subject(s)
Full text: Available Database: WPRIM (Western Pacific) Main subject: Pathology / Stomach Neoplasms / Vascular Endothelial Growth Factor C / Lymphangiogenesis / Cyclooxygenase 2 / Lymph Nodes / Lymphatic Metastasis / Metabolism Limits: Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2005 Document type: Article
Full text: Available Database: WPRIM (Western Pacific) Main subject: Pathology / Stomach Neoplasms / Vascular Endothelial Growth Factor C / Lymphangiogenesis / Cyclooxygenase 2 / Lymph Nodes / Lymphatic Metastasis / Metabolism Limits: Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Gastrointestinal Surgery Year: 2005 Document type: Article
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