Advance in research on the function of telomeric shelterin component TPP1 and its relationship with characteristics of tumors / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 573-577, 2016.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-345406
Responsible library:
WPRO
ABSTRACT
As an important telomere binding protein, TPP1 protects the ends of telomeres and maintains the stability and integrity of its structure and function by interacting with other five essential core proteins (POT1, TRF1, TRF2, TIN2, and RAP1) to form a complex called Shelterin. Recently, researchers have discovered that TPP1 participates in protection of telomeres and regulation of telomerase activity. The relationship between TPP1 and tumorigenesis, tumor progression and treatment has also been investigated. This paper reviews the latest findings of TPP1 regarding to its structure, function and interaction with other proteins involved in tumorigenesis.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Physiology
/
DNA Damage
/
Chemistry
/
Telomere
/
Telomere-Binding Proteins
/
Chromosomal Instability
/
Genetics
/
Neoplasms
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2016
Document type:
Article