Changes in Th17 and CD4+CD25+ Treg cells and their significance among children with hand, foot and mouth disease / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1113-1115, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-345634
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the changes in peripheral blood Th17 and CD4(+)CD25(+) regulatory T (Treg) cells and their significance among children with hand, foot and mouth disease (HFMD).</p><p><b>METHODS</b>Eighty-nine children with HFMD, including 55 cases of common HFMD and 34 cases of severe HFMD, were included in the study; and 30 healthy children were selected as the control group. The percentages of Th17 and CD4(+)CD25(+) Treg cells in CD4(+) T cells in peripheral blood were determined by flow cytometry. The expression levels of interleukin (IL)-10, transforming growth factor-β (TGF-β), and IL-17 were measured by enzyme-linked immunosorbent assay.</p><p><b>RESULTS</b>Compared with the control group, the cases of common HFMD and severe HFMD had significantly increased levels of Th17 cells and IL-17 (P<0.05) but significantly decreased levels of CD4(+)CD25(+) Treg cells, IL-10, and TGF-β (P<0.05). The severity of the HFMD was positively correlated with the levels of Th17 cells and IL-17 in peripheral blood but negatively correlated with the levels of CD4(+)CD25(+) Treg cells, IL-10, and TGF-β.</p><p><b>CONCLUSIONS</b>Children with HFMD have increased response of Th17 cells but decreased response of CD4(+)CD25(+) Treg cells in peripheral blood. Th17/CD4(+)CD25(+) Treg cell imbalance may play an important role in the pathogenesis of HFMD.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Blood
/
Transforming Growth Factor beta
/
Interleukin-10
/
T-Lymphocytes, Regulatory
/
Interleukin-17
/
Allergy and Immunology
/
Th17 Cells
/
Hand, Foot and Mouth Disease
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2013
Document type:
Article