Association between polymorphism of RAD50 gene and acute lymphoid leukemia in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 469-471, 2015.
Article
in Zh
| WPRIM
| ID: wpr-346125
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between single nucleotide polymorphism (SNP) (rs17166050) in RAD50 gene and acute lymphoid leukemia (ALL) in children.</p><p><b>METHODS</b>A total of 177 ALL children from Wuhan and surrounding areas and 232 healthy children were selected. The numbers of standard-risk, medium-risk, and high-risk children were 66, 69, and 42, respectively. The genotypes of SNP in RAD50 gene were determined using PCR-RFLP, and the relationship of the RAD50 polymorphism with ALL susceptibility and clinical risk was analyzed.</p><p><b>RESULTS</b>The genotype (AA, GA, and GG) distribution of SNP in RAD50 gene showed significant differences between the ALL and control groups (P=0.038), and G allele was significantly associated with ALL susceptibility (OR=1.459, 95% CI: 1.034-2.057, P=0.031). However, the SNP was not associated with the risk stratification of ALL.</p><p><b>CONCLUSIONS</b>The SNP (rs17166050) in RAD50 gene is associated with the susceptibility to ALL in children, but is not associated with the risk stratification of ALL.</p>
Full text:
1
Database:
WPRIM
Main subject:
Risk
/
Genetic Predisposition to Disease
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Polymorphism, Single Nucleotide
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DNA Repair Enzymes
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DNA-Binding Proteins
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Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Genetics
Type of study:
Etiology_studies
/
Risk_factors_studies
Limits:
Child
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Child, preschool
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Female
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Humans
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Infant
/
Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2015
Document type:
Article