Protective effect of yixinshu capsule on myocardial ischemia reperfusion injury in rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 2005-2008, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-346454
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the protective effect of Yixinshu capsule on myocardial ischemia reperfusion injury (MIRI) in SD rats.</p><p><b>METHOD</b>Sixty healthy SD rats were randomized into six groups sham group, MIRI model group, Xinsuning capsule group, low, middle or high dose Yixinshu capsule. Acute MIRI rat models were created by reperfusion for 120 min after anterior interventricular branch of the left coronary artery for 30 min. The serum creatine kinase (CK), lactic dehydrogenase (LDH), aspartate aminotransferase (AST) and malondialdehyde(MDA), blood viscosity, and infarction area of myocardium were determined.</p><p><b>RESULT</b>Yixinshu capsule could reduce serum CK, LDH, AST and LDH activity, improve the blood viscosity, and reduced the myocardial infarct size.</p><p><b>CONCLUSION</b>Yixinshu capsule can protect against MIRI in rats.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Blood Viscosity
/
Capsules
/
Drugs, Chinese Herbal
/
Lipid Peroxidation
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Myocardial Reperfusion Injury
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Rats, Sprague-Dawley
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Therapeutic Uses
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Drug Therapy
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Document type:
Article