An antimetastatic study of Arg-Asp (RD) on salivary adenoid cystic carcinoma in vivo / 中华口腔医学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To test the antimetastatic effects of Arg-Asp (RD) on salivary adenoid cystic carcinoma (SACC-LM) in vivo.</p><p><b>METHODS</b>RD was administered orally to experimental metastasized nude mice. The pulmonary metastatic foci number and survival were determined to assay the antimetastatic effects of RD.</p><p><b>RESULTS</b>30 mg/kg, 120 mg/kg of RD demonstrated an inhibitory effect on the pulmonary metastatic foci formation. All of the tested dosages (7.5 mg/kg, 30 mg/kg, 120 mg/kg) of RD prolonged the survival.</p><p><b>CONCLUSIONS</b>Oral administration of RD has a antimetastatic effect on SACC-LM. RD is low toxicity.</p>