Biological characteristics of T-lineage acute lymphoblastic leukemia in 23 children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 605-608, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-347532
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the biological characteristics of childhood T-lineage acute lymphoblastic leukemia (T-ALL) and their clinical significance.</p><p><b>METHODS</b>Immunophenotyping was performed by three-color flow cytometry analysis using CD45 /SSC gating in 23 children with newly diagnosed T-ALL. Meanwhile cytogenetic analysis was performed.</p><p><b>RESULTS</b>CD3(+) expression of T-lineage antigens was apparently higher than CD7(+) and CD5(+) expression. CD19(+) expression of B-lineage antigens was apparently higher than CD22(+), CD10(+) and CD20(+) expression. Myeloid antigen was expressed in 4 cases (17%). CD34(+) and HLA-DR(+) were observed in 4 cases (17%) and 5 cases (22%), respectively. cCD3(+) and cCD79(+) were expressed in 23 cases (100%) and 22 cases (96%), respectively. The chromosome detection in 8 cases with T-ALL showed hyperdiploid or Ph(+) chromosome (one case each). The fusion gene detection in 5 cases showed MLL rearrangements in two cases and positive SIL/TAL1 fusion gene in one case. CD3 expression was related with the complete remission rate.</p><p><b>CONCLUSIONS</b>Immunophenotyping is an important tool for diagnosis of T-ALL. However, the immunophenotype of T-ALL is heterogeneous. So, immunophenotyping along with cytogenetic and molecular genetic analysis is needed in the treatment and prognosis evaluation of T-ALL.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Immunophenotyping
/
Chromosome Aberrations
/
Drug Therapy
/
Allergy and Immunology
/
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
/
Genetics
Type of study:
Prognostic study
Limits:
Child
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Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2010
Document type:
Article