Clinical application of proton magnetic resonance spectroscopy in children with idiopathic epilepsy / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 425-428, 2010.
Article
in Zh
| WPRIM
| ID: wpr-347580
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>This study examined the biochemical metabolism by proton magnetic resonance spectroscopy ('H-MRS) in order to explore the value of 'H-MRS in idiopathic epilepsy in children.</p><p><b>METHODS</b>Thirty-three children with idiopathic epilepsy (14 cases with history of febrile seizures and 19 cases without) and six normal controls experienced MRI of the skull and brain and single-voxel 'H-MRS examinations of the hippocampi-temporal lobe. The signal intensities of N-acetylaspartate (NAA), eatine+phosphocreatine (Cr), choline-containing compounds (Cho) and lactate (Lac) and the ratios of NAA/ (Cho+Cr) and Lac/Cr were compared between the patients and normal controls.</p><p><b>RESULTS</b>MRI examination showed that only one child with epilepsy had myelin dysplasia. 'H-MRS examination showed that the ratio of NAA/ (Cho+Cr) in the epilepsy group was lower than that in the control group (0.64+/-0.07 vs 0.73+/-0.05; P<0.01). The epileptic children with history of febrile seizures had a more decreased ratio of NAA/ (Cho+Cr) compared with those without the history (0.61+/-0.07 vs 0.66+/-0.06; P<0.05). There were no significant differences in the ratio of Lac/Cr between the epilepsy and the control groups.</p><p><b>CONCLUSIONS</b>'H-MRS may provide early information on brain injury sensitively and non-invasively in children with epilepsy. It may be used for diagnosis and prognosis evaluation of epilepsy.</p>
Full text:
1
Database:
WPRIM
Main subject:
Phosphocreatine
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Protons
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Magnetic Resonance Imaging
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Magnetic Resonance Spectroscopy
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Choline
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Aspartic Acid
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Diagnosis
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Epilepsy
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Metabolism
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Methods
Type of study:
Diagnostic_studies
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Prognostic_studies
Limits:
Child
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Child, preschool
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Female
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Humans
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Male
Language:
Zh
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2010
Document type:
Article