A potential mechanism for impaired wound healing--cutaneous environmental disorders in diabetes mellitus / 中华烧伤杂志
Chinese Journal of Burns
; (6): 3-5, 2008.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-347653
Responsible library:
WPRO
ABSTRACT
Impaired wound healing in diabetes is a significant clinical problem which is thought to be associated with neuropathy and angiopathy previously . The present study indicates that accumulation of glucose and glycometabolic products in skin tissue, as the result of glycometabolic disorders, which contributes to cutaneous environmental alterations in diabetes mellitus, and subsequently induces the abnormal cell behaviors, cytokine alteration and matrix modification. Thus, diabetic neuropathy and angiopathy might be regarded as the pathological outcome of cutaneous environmental alterations. In conclusion, glycometabolism disorders could be described as one of the initial events for the alteration involving in the underlying cutaneous disorder which impair healing process. The related research focuses on the initial event of controlling disorders in wound healing and therefore contribute to providing the strategy of treatment as based on these approaches.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Skin
/
Wound Healing
/
Diabetes Mellitus
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Burns
Year:
2008
Document type:
Article