Study on the changes of IL-3 and its receptor in mice with immune-mediated aplastic anemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 684-686, 2004.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-347885
Responsible library:
WPRO
ABSTRACT
The aim of this study was to find new idea for clinical treatment of aplastic anemia. Immune-mediated aplastic anemia mice were developed, IL-3 in the supernatant with PHA stimulating splenic cells was detected by ELISA, semi-quantiting analysis of IL-3R was performed by point hybridization. The results showed that the IL-3 level in the supernatant with PHA stimulating splenic cells of immune-mediated aplastic anemia mice was higher than controls, difference between them was significant (P <0.001), while amount of IL-3 receptor by semi-quantiting analysis was lower than control significantly. In conclusion, the IL-3 receptor expression level is important for pathogenesis and treatment strategy of aplastic anemia.
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Bone Marrow
/
RNA, Messenger
/
Receptors, Interleukin-3
/
Interleukin-3
/
Allergy and Immunology
/
Genetics
/
Anemia, Aplastic
/
Mice, Inbred BALB C
/
Mice, Inbred DBA
Limits:
Animals
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2004
Document type:
Article