Association of cyclic adenosine monophosphate response element-binding protein gene and major depressive disorder / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 263-266, 2010.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-349000
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between single nucleotide polymorphisms (SNPs) in cyclic adenosine monophosphate response element-binding protein(CREB1) gene and major depressive disorder (MDD).</p><p><b>METHODS</b>We recruited 105 parent-offspring trios of Chinese descent, extracted whole blood genomic DNA, and genotyped the SNPs in rs10932201 and rs6740584 loci. Single-marker transmission disequilibrium test (TDT), pairwise SNP linkage disequilibrium(LD) and haplotype-based TDT were performed.</p><p><b>RESULTS</b>No significant association with MDD was observed for SNPs rs10932201 and rs6740584 (P=0.1004 and P=0.4986). However, there was strong positive association between the rs10932201-rs6740584 haplotype and MDD (P=0.00003241), and both haplotypes of A-C and A-T were significantly associated with MDD (P=0.020 and P=0.00022).</p><p><b>CONCLUSION</b>The rs10932201-rs6740584 haplotype of the CREB1 gene may play an important role in the pathogenesis of MDD.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Haplotypes
/
Cyclic AMP Response Element-Binding Protein
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
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Depressive Disorder, Major
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Genetics
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2010
Document type:
Article