Research advance on the role of ubiquitin proteasome pathway in acute promyelocytic leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 232-236, 2014.
Article
in Zh
| WPRIM
| ID: wpr-349730
Responsible library:
WPRO
ABSTRACT
Acute promyelocytic leukemia (APL) is characterized by PML-RARa expression. Ubiquitin proteasome-pathway (UPP) plays a key role in all-trans retinoid acid (ATRA) and arsenic trioxide (ATO)-induced degradation. In addition, the regulations of cell cycle and transcription are also related to this pathway. Deeply studying the role of ubiquitin-proteasome pathway in APL contributes to elucidate the mechanisms of some drugs and explode the clinical therapeutical insight for APL. In this article, the constitution of UPP, the role of UPP-mediated protein modification in APL, the application of ubiquitination-associated drugs in APL are reviewed.
Full text:
1
Database:
WPRIM
Main subject:
Leukemia, Promyelocytic, Acute
/
Ubiquitin
/
Proteasome Endopeptidase Complex
/
Metabolic Networks and Pathways
Limits:
Humans
Language:
Zh
Journal:
Journal of Experimental Hematology
Year:
2014
Document type:
Article