Study of the gene expression pattern in the Kkay mouse with type 2 diabetes by genomic-scale gene expression analysis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 462-465, 2002.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-350084
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the genes differentially expressed in the liver of Kkay diabetic and normal mice by genomic-scale gene expression analysis.</p><p><b>METHODS</b>cDNA microarray chips containing 8,192 cDNAs were used to explore the gene expression pattern of Kkay mouse liver.</p><p><b>RESULTS</b>One hundred and fifty-four genes were screened out, including 68 complete cDNAs and expressed sequence tags, and among them 40 genes were up-regulated and 114 genes were down-regulated respectively.</p><p><b>CONCLUSION</b>Most of the gene expression analysis results were consistent with previous study, and the gene expression pattern of Kkay mouse based on cDNA microarray could be used for high-throughout screening out the genes associated with type 2 diabetes.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Gene Expression
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
/
Diabetes Mellitus, Experimental
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Diabetes Mellitus, Type 2
/
Genetics
/
Liver
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Metabolism
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Mice, Mutant Strains
Limits:
Animals
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2002
Document type:
Article