Real-time three-dimensional echocardiographic assessment of left ventricular diastolic dyssynchrony and dysfunction in hypertrophic cardiomyopathy / 南方医科大学学报
Journal of Southern Medical University
; (12): 8-12, 2013.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-352319
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To assess left ventricular (LV) regional diastolic function in patients with hypertrophic cardiomyopathy (HCM) using single-beat real-time three-dimensional echocardiography (RT-3DE).</p><p><b>METHODS</b>Sixty-nine patients with HCM (LV ejection fraction≥45%) and 50 normal control subjects underwent examinations by two-dimensional echocardiography (2DE) and RT-3DE. The parameters analyzed by RT-3DE included the end diastolic sphericity index (EDSI), diastolic dyssynchrony index (DDI), dispersion end diastole [DISPED, including late (DDI-late) and early (DDI-early) diastole, dispersion end diastole (DISPED-late), and dispersion early diastole (DISPED-early)]. The patients were divided into 3 groups with impaired relaxation (n=23), pseudonormal filling (n=37), and restrictive filling (n=9).</p><p><b>RESULTS</b>DDI and DISPED increased with the severity of diastolic dysfunction. In end diastole, DDI-late and DISPED-late were abnormal in cases with severe diastolic dysfunction (7.95∓2.75 and 26.76∓17.19, respectively, P<0.0001) but normal in cases with mild diastolic dysfunction. In early diastole, DDI-early and DISPED-early both increased in cases of mild (8.57∓2.24 and 25.44∓6.31, respectively, P<0.0001) and moderate (9.56∓4.66 and 35.42∓14.19, respectively, P<0.0001) diastolic dysfunction.</p><p><b>CONCLUSION</b>In patients with HCM, dyssynchrony in early diastole is more obvious than that in late diastole and shows also a stronger correlation with diastolic dysfunction. This preclinical lesion can be detected by single-beat RT-3DE.</p>
Full text:
Available
Database:
WPRIM (Western Pacific)
Main subject:
Cardiomyopathy, Hypertrophic
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Diagnostic Imaging
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Case-Control Studies
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Ventricular Dysfunction, Left
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Echocardiography, Three-Dimensional
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Diastole
Type of study:
Diagnostic study
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Observational study
Limits:
Adult
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Female
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Humans
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Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2013
Document type:
Article